Sajid Javid has said he will not stand again as an MP at the next general election.
In a letter published on Friday, Javid said the decision was one he had “wrestled with for some time”.
The 52-year-old has been the MP for Bromsgrove since 2010 and has held many senior cabinet jobs including chancellor, home secretary and health secretary.
He unsuccessfully stood in the leadership race triggered when Boris Johnson was ousted earlier this year.
Javid is the latest Tory MP to announce he will quit rather than fight what looks likely a losing election for the party.
Former work and pensions secretary Chloe Smith has already said she will stand down, as has 29-year-old rising star Dehenna Davison.